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Home-cage monitoring spontaneous activity of C57BL/6J male mice 3 months after open-field low-intensity blast exposureDOI:10.34945/F5FK5CDATASET CITATIONZuckerman A., Siedhoff H. R., Balderrama A., Cui J., Gu Z. (2023) Home-cage monitoring spontaneous activity of C57BL/6J male mice 3 months after open-field low-intensity blast exposure. Open Data Commons for Traumatic Brain Injury. ODC-TBI:871 http://doi.org/10.34945/F5FK5CABSTRACTSTUDY PURPOSE: Evaluate the chronic-phase behavioral alterations 3 months after exposure to low-intensity blast in a home-cage-like environment.DATA COLLECTED: A total of 52 male C57Bl/6J mice, 8 weeks old, were used. The mice were randomly allocated into one of two groups: Blast (n=29) or Sham (n=23). Mice in the Blast group were exposed to open-field low-pressure blast wave (46.6 kPa, maximum impulse of 60.0 kPa*ms), under anesthesia. Mice from the Sham group were anesthetized but were not exposed to the blast wave. 3 months post-exposure, the spontaneous activity of the mice was measured using the PhenoTyper® home-cages (L = 30 × W = 30 × H = 35 cm; Model 3000, Noldus Information Technology, The Netherlands). Each mouse was housed individually, and its activity was continuously measured for 72 hours at a sample rate of 15 fps. Program-acquired data were uploaded to the web-based AHCODA-DB (Sylics, Bilthoven, The Netherlands) for meta-analysis. Twenty behavioral parameters were analyzed and included in this dataset. See protocols and other related data in the relevant links section below.CONCLUSIONS: No significant differences were found between the Blast and Sham mice in different parameters of general daily performance behaviors, such as activity, arrests, and feeding zone visits. Although no significant difference in long shelter visits between the Blast and Sham mice, was found, significant differences were found in multiple parameters of short shelter visits such as “shelter visit threshold” and “short shelter visit duration” (relevant to anxiety-like behaviors). Blast mice visited their shelters more frequently and for shorter periods of time than Sham mice in both dark and light phases. These results suggest that LIB-exposed mice may hold stable perceptions of environmental stimuli as a threat during activity bouts, whereas sham controls experienced such responses to a lesser degree. This type of performance is consistent as trait anxiety in humans, defined as a tendency to respond with concerns, troubles, and worries to non-threatening situations.KEYWORDSprimary open-field blast; home-cage monitoring; PhenoTyper; spontaneous activity; anxiety-like behaviorsPROVENANCE / ORIGINATING PUBLICATIONS
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DATASET INFOContact: Gu Zezong (guze@health.missouri.edu)Lab: PRECISE-TBI Lab: Truman Memorial VA
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